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Chunk #32 — Discussion

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Large-scale genome-wide association study of Asian population reveals genetic factors in FRMD4A and other loci influencing smoking initiation and nicotine dependence.
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are highly correlated in the Korean population (r2 = 0.98) and the European population (r2 = 0.85, HapMap CEU). However, a low correlation was observed in an African population (r2 = 0.013, HapMap YRI). As shown in Table 2, rs848353 and rs1404697 demonstrate a great difference in allele frequency in the AA sample (0.05 for rs1404697 and 0.32 for rs848353). Also note that rs848353 was replicated in the AA sample, whereas rs1404697 was not.