Of a note, we found that the mode of inheritance that provided the most significant association results also differed from population to population. This is probably attributable to the fact that genetic diversity among populations accounts for the replicated association under different genetic inheritance models in samples with different ancestry. For 7q31.1, the additive model provided the strongest signal in the discovery stage, whereas the dominant model provided the strongest signal in the AA replication sample. For RGS17, the additive model provided the strongest signal in the discovery sample, whereas the recessive model provided the strongest signal in the EA replication sample.
