Results showed that 3xTg-AD mice exhibited a deficit in acquisition of spatial learning that was not altered by alcohol exposure (Fig. 5A, left), which is consistent with known performance of this mouse strain (Huber et al., 2018). Three-way RM-ANOVA (genotype alcohol trial) identified a significant main effect of trial [F(2.006, 24.07) = 3.511, P = 0.0458] and genotype [F(1, 12) = 7.841, P = 0.02]. However, there was no main effect of alcohol exposure or an interaction among the variables.
