These data show that 3xTg-AD mice at 7months of age exhibit a deficit in spatial learning as demonstrated by increased escape latencies during the acquisition phase of the MWM test irrespective of treatment condition. This result is consistent with prior evidence showing that at 6months of age, 3xTg-AD mice require more trials to reach criterion (escape latency) when learning the MWM task, which was demonstrated by single-trial analysis to be a function of impaired memory function during the multi-day procedure (Billings et al., 2005).
