Importantly, there is no evidence in the present study that a history of alcohol intake altered spatial learning by 3xTg-AD mice or WT controls. However, since neural (Oddo, Caccamo, Shepherd, et al., 2003) and behavioral (Garvock-de Montbrun et al., 2019) pathology continues to develop in 3xTg-AD mice after 12 months of age, it will be important for future studies to evaluate the impact of alcohol use on spatial learning in older mice.
