Differential wiring which is necessarily related to DV, provided a measure of how selection affects the interaction (connectivity) of each gene with the entire coexpression network. Similar to our previous results (Colville et al., 2017; Iancu et al., 2018), we observed that selection has marked effects on DW and this was true across all regions, with the effects somewhat more prominent in the CeA and SH than the PL. The large DW effect associated with selection is largely silent in most analyses of coexpression data, even though the data illustrate here that the rewiring of the coexpression system is perhaps the most profound change in the transcriptome. There were 71 common DW genes across the three brain regions and this core group was significantly enriched in genes associated with the post-synaptic membrane. The genes in this category included Chrna7, Als2, Ppp1r9a, Strn, Kcna4, Kif1a, and Slc1a2. Slc1a2, which encodes for the excitatory amino acid transporter 2 (EAAT2) and is the principal transporter within the brain for glutamate, is of interest given the focus on excitatory neurotransmission above and evidence that
