amenable to cell culture manipulations, such as trypsinization, compared to mature cortical interneurons with elaborate branching patterns. In fact, we have shown that these maturing interneurons demonstrate efficacy in ameliorating seizure activity even before attaining full maturation [29]. These developmental interneurons could also provide valuable resources for modeling neurodevelopmental diseases, such as schizophrenia, enabling us to model early developmental time points, during which time the developing brains are known to be more susceptible to environmental challenges [40–42]. This is especially relevant, since many known schizophrenia risk genes are highly expressed during early development [43–45].
