In our data, the chromosome 1 variant showed nominal association with multiple AD criteria and the criterion count, but none at GWS levels. However, a highly correlated variant (rs1890881) was associated at GWS with a phenotype representing dependence on alcohol or illicit drugs (cannabis, cocaine, sedatives, stimulants, opioids) in the same sample (see accompanying paper by Wetherill et al). It is possible that this variant is associated with overall liability to AD and dependence on other drugs but to a lesser extent with AD severity as indexed by a single continuous criterion count. Research has noted that mere summation does not capture the heterogeneity underlying AD severity, where constellations of criteria could result in meaningful individual differences 10. Prior latent class analyses aimed to parse out such groups of individuals with unique sets of criteria including in a subset of these data 9. However, assessment of the genomic underpinnings of such heterogeneous groups of individuals would require extremely large sample sizes. The chromosome 8 variant, rs188227250, was uniquely associated with Drinking more than intended (Supplemental Table 7). In epidemiological studies
