The region on chromosome 8 has been linked to bipolar disorder 65. The only gene near the chromosome 8 region is FAM84B (Supplemental Figure 4D), however, this gene doesn’t seem to be related any neuropsychiatric diseases. The chromosome 15 region harbors some non-coding RNAs (Supplemental Figure 4E) and was previously linked to the rate of cognitive decline 55, ADHD 66, and major depression 67. Thus, despite our discovery of novel loci, much further study is needed to investigate the role of these variants in the etiology of alcohol dependence and related traits.
