The GWS findings for the other loci are novel and have not been previously reported for AD or related phenotypes, although these regions have been linked to some neuropsychiatric diseases/traits. The region on chromosome 1 was previously linked to cerebrospinal fluid biomarker level 55, migraine 56, illegal substance dependence 57, and neuroticism 58. This region encompasses gene RABGAP1L, with many other genes nearby (Supplemental Figure 4A). RABGAP1L is broadly expressed in brain regions and showed association with cerebrospinal fluid biomarker levels55, and migraine 56. Other genes near this region seem interesting too, e.g. KIAA0040, which is downstream of this region, was associated with alcohol dependence59. The chromosome 2 region is in a gene desert (Supplemental Figure 4B) and has been linked to cognitive test scores 60, ADHD symptom count 61, ADHD 62, current smoking 63, and juvenile myoclonic epilepsy 64. The region on chromosome 8 has been linked to bipolar disorder 65. The only gene near the chromosome 8 region is FAM84B (Supplemental Figure 4D), however, this gene doesn’t seem to be related any neuropsychiatric diseases. The chromosome 15 region
