1·5 Mb of the peak SNP with association p values less than 10−4 and r2 less than 0·2 with the peak SNP based on HapMap 3 CEU data. For the chromosome 3p21 region, and regions CACNA1C and CACNB2, no additional independent association signals were detected. For the chromosome 10q24 region, an additional SNP (rs11191732), about 600 kb from the peak SNP, showed association after conditioning on the peak SNP (rs11191454) with a p value of 6·60×10−6 before conditioning and 3·88×10−5 after conditioning. Several loci previously implicated in PGC analyses of schizophrenia and bipolar disorder6,7 showed evidence for association in the cross-disorder analysis, despite not exceeding the cutoff for genome-wide significance (appendix pp 23–24). These loci include one near MIR137, TCF4, the MHC region on chromosome 6, and SYNE1 (appendix pp 23–24). The five-degree-of-freedom χ2 test did not identify any additional genome-wide significant SNPs with effects in the opposite direction among the five disorders (appendix pp 36–37).
