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Chunk #4 — Introduction

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Electroencephalographic Cross-Frequency Coupling as a Sign of Disease Progression in Patients With Mild Cognitive Impairment: A Pilot Study.
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In the current study, we investigated the differences in gamma/theta CFC between AD, MCI, and HC and the differences in patients with pMCI compared to patients with sMCI. Our hypothesis was that patients with AD showed lower gamma/theta CFC compared to both MCI and HC and that pMCI showed lower gamma/theta CFC than sMCI. In an exploratory manner, we also examined the changes in CFC in multiple frequency bands. Lastly, we investigated the association between gamma/theta CFC and both cognitive function and cerebrospinal fluid (CSF) markers in AD.