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Chunk #27 — Results — Associations with Cognitive/Psychiatric Phenotypes

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Linking genes, circuits, and behavior: network connectivity as a novel endophenotype of externalizing.
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Overall, the externalizing PS explained approximately 5% of the variance in inhibitory control (p = .016), and the neural network parameters (combined) explained approximately 8% of the variance in inhibitory control (p = .023). The combined variance explained across the genomic and neural levels of analysis was also significant (R2 = .10, p = .016). In contrast, the variance explained by the externalizing PS (1%), neural network parameters (4%), and combined genomic and neural levels of analysis (4%) was not significant for alcohol/substance use disorders.