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Chunk #26 — Results — Associations with Cognitive/Psychiatric Phenotypes

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Linking genes, circuits, and behavior: network connectivity as a novel endophenotype of externalizing.
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Mean connectivity in the network was negatively associated with performance on inhibitory control tasks (β = −.21, p = .015, ΔR2 = .04) and with a greater likelihood of a lifetime alcohol or substance use diagnosis (Wald X2= 4.9, p = .026, ΔR2 = .03), indicating that hyper-connectivity in the network confers risk for externalizing phenotypes. Examination of the graph properties revealed an inverse association between right amygdala Participation Coefficient and inhibitory control (β = −.24, p = .005, ΔR2 = .05), but no associations emerged for alcohol/substance use diagnosis.