The only true trans-association significantly identified among ADME genes comprised six SNPs in the plasminogen (PLG) gene on chromosome 6, a zymogen of the serine protease plasmin, which were associated to expression of a distant serine protease UNQ9391(PRSS55) on chromosome 8. As depicted in Figure 4, three of the variants (rs1406891, rs783145 and rs1247558) are simultaneously locally associated with expression of PLG itself, thus substantiating functional impact. Whereas rs1247558 and rs1406891 are located in intergenic regions, rs783145 is located in an intron, suggesting that this or a closely linked variant might be the causative SNP.
