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Chunk #19 — Discussion

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Genomics of ADME gene expression: mapping expression quantitative trait loci relevant for absorption, distribution, metabolism and excretion of drugs in human liver.
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Several studies11, 12, 13, 14, 15, 16, 17, 18, 19 have shown the utility of eQTL analysis to elucidate relationships between genetic polymorphisms and gene expression on a genome-wide scale, thus contributing to understanding the genetic basis of inter-individual variability and heritability of complex traits. However, limited information is so far available regarding completeness, reproducibility and interpretation of such data.