PIP>0.95 SNPs tag a large proportion of the SNP-heritability (hg2) tagged by lead GWAS SNPs (median proportion=42%) but a small proportion of total genome-wide hg2 (median proportion=19%) (Figure 2b), implying that they causally explain a small proportion of hg2. We thus propose polygenic localization, whose aim is to identify a minimal set of common SNPs causally explaining a specified proportion of common SNP heritability. A key difference between polygenic localization and previous studies of polygenicity34–38 is that polygenic localization aims to identify (not just characterize) such SNPs.
