Consistent with our hypotheses, we demonstrated that 1) youth without dense family histories of AUD produced a network of brain activity that resembled the OA model more than that of the FHP comparison group as illustrated by overall fit indices, and 2) FHP youth demonstrated a statistically significant stronger regression coefficient for the bilateral pathway between the right superior parietal lobule to left middle frontal gyrus. Removal of the bilateral pathway from the FHP model decreased overall fit indices much more than when it was removed from the FHN group, underscoring the extent of group differences. The difference between FHN and FHP remained unchanged after controlling for SWM performance, which was slightly superior in FHP youth, suggesting that this difference is not mediated by SWM performance. These data contribute to the growing evidence that familial history of AUD may influence neurobehavioral correlates and thus contribute to increased rates of problem drinking in FHP youth.
