Figure 1 graphically depicts the associations between GPRS with LCA-based typical and atypical subtype estimated by multinomial logistic regressions (associations with MDD are also depicted as benchmark for comparison; full results including moderate subtype are available in eTables 2,3). In general, GPRS for psychiatric traits were also associated with both severe subtypes, but the associations were stronger with typical, especially for GPRS-SCZ2 (Pt<0.5:OR=1.54,95%CI=1.33–1.78, p=7.8e-9). GPRS-SCZ2 explained up to 1.3% of the variance for atypical, similar to MDD, and up to 2.4% for typical MDD (Figure 2C,E)
