No association was found for GPRS of metabolic traits with MDD (Figure 1; eTable 1). Among the metabolic traits GPRS-BMI (Pt<0.0001:OR=1.29,95%CI=1.12–1.47, p=2.7e-4) and GPRS-TG (Pt<0.005:OR=1.21,95%CI=1.06–1.38, p=0.006) were associated with atypical MDD, particularly at stringent Pts. Cross-correlation between GPRS-BMI and GPRS-TG was low even at Pt<1 including all independent SNPs (r=0.04;p=0.02). When including both GPRS in the same model they remained independently associated with atypical in Pt bins <0.0001, <0.001, <0.005,<0.01 and 0.05. Figure 1F shows that GPRS-BMI explained up to 1.2% and GPRS-TG up to 0.5% of the variance for atypical MDD. GPRS for metabolic traits were not associated with typical MDD (Figure 1, eTable 3) Association analyses between LCA-based subtypes with all GPRS were repeated after lowering the cut-off for classification precision (average posterior probability > 0.6, including up to ~90% of the available subjects with symptom-level data) and results were very similar (data not shown).
