Regression analysis of chr15q25.1 SNPs evaluated SNP effects excluding dependence covariates. Multiple mediation analyses tested whether nicotine dependence measures mediated the association of rs1051730 with 6MO abstinence, controlling for other chr15q25.1 SNPs, demographics, population genetic variation and relevant RCT arms [70]. Receiver operating characteristic (ROC) analyses of abstinence compared the contribution of nicotine dependence and genetic variables to a base model with demographic variables. Statistical analyses were performed in STATA 12.0 (StataCorp, College Station, TX, USA). Power analyses were performed using Quanto [71]. Alpha for all tests was 0.05.
