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Chunk #13 — Methods — Logistic Modeling of the Effect of SNPs on EOT and 6MO abstinence

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Nicotinic acetylcholine receptor variation and response to smoking cessation therapies.
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(presence or absence of college degree), gender, marital status (married or other)], dependence measures [FTND and CPD (coded as in the FTND)], interactions with demographic variables (CPD x age, CPD x gender and FTND x gender), the first ten principal components of population genetic variation, and indicator variables for the 26 RCT arms and the PGs. These analyses were performed as regression analyses including all 2,633 individuals simultaneously, thus the number of variables is a small fraction (~2%) of the number of individuals. Regression analyses assessed the homogeneity of SNP effects between PGs, and quantified SNP effects across all PGs.