Chunk #55 — Results — The cellular population structure differs between ADAD vs LOAD

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Genetic variants associated with Alzheimer's disease confer different cerebral cortex cell-type population structure.

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× 10−032.41 × 10−01Clinical Dementia Rating ADa and Controls110− 0.022.66 × 10−020.035.48 × 10−03− 0.012 × 10−01− 4.63 × 10−044.77 × 10−01 ADAD and Controls26− 0.084.12 × 10−040.111.78 × 10−070.014.03 × 10−03− 1.55 × 10−031.75 × 10−08 LOAD and Controls100− 0.023.22 × 10−020.037.01 × 10−03− 0.011.81 × 10−01− 4.64 × 10−045.11 × 10−01Braak staging ADa and Controls106− 0.038.51 × 10−060.033.83 × 10−06− 4.24 × 10−032.04 × 10−01− 2.52 × 10−046.81 × 10−01 ADAD and Controls33− 0.052.37 × 10−050.062.45 × 10−05− 0.012.29 × 10−01− 7.2 × 10−044.89 × 10−01 LOAD and Controls88− 0.037.41 × 10−040.034.63 × 10−04− 3.72 × 10−033.29 × 10−01− 1.66 × 10−047.86 × 10−01aAD includes both autosomal dominant AD (ADAD) and late-onset AD (LOAD)The cellular population structure was inferred using the ssNMF method. Effects and p-values for the association with disease status, clinical dementia rating and Braak staging using generalized mixed models. We identified similar trends with approximately the same significance levelsAD Alzheimer’s disease, ADAD autosomal dominant AD, LOAD late-onset AD