Chunk #54 — Results — The cellular population structure differs between ADAD vs LOAD

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Genetic variants associated with Alzheimer's disease confer different cerebral cortex cell-type population structure.

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2.66 × 10−02 for neurons and β = 0.03 and p = 5.48 × 10−03 for astrocytes; Table 3; Fig. 3c). We did not observe a significant difference in the compositions of microglia or oligodendrocytes (Table 3; Additional file 1: Figure S8).Table 3Cellular population structure altered in the parietal lobe from AD brains in the DIAN study and Knight-ADRC brain bankDisease statusSample sizeNeuronAstrocyteOligodendrocyteMicroglia n Effectp valueEffectp valueEffectp valueEffectp valueAD status ADa vs Control122− 0.115.52 × 10−040.142.48 × 10−05− 0.036.5 × 10−02− 2.64 × 10−032.49 × 10−01 ADAD vs Control38− 0.193.94 × 10−070.241.57 × 10−10− 0.048.5 × 10−03− 0.017.77 × 10−05 LOAD vs Control100− 0.095.67 × 10−030.123.34 × 10−04− 0.021.06 × 10−01− 1.70 × 10−034.57 × 10−01 ADAD vs LOAD Braak matched42− 0.081.03 × 10−020.119.26 × 10−04− 0.037.1 × 10−02− 1.46 × 10−037.01 × 10−01 Braak corrected91− 0.094.71 × 10−030.115.24 × 10−04− 0.021.77 × 10−01− 2.41 × 10−034.25 × 10−01 CDR corrected94− 0.122.11 × 10−030.136.29 × 10−04− 0.023.8 × 10−01− 3.11 × 10−032.41 × 10−01Clinical Dementia Rating ADa and Controls110− 0.022.66 × 10−020.035.48 × 10−03− 0.012 × 10−01− 4.63 × 10−044.77 × 10−01 ADAD and Controls26− 0.084.12 × 10−040.111.78 × 10−070.014.03 × 10−03− 1.55 × 10−031.75 × 10−08 LOAD and Controls100−