were immediately snap frozen in liquid nitrogen. The post-mortem interval (PMI) was calculated from the time of death to the time of removal of the brain from the skull. The total number of samples processed from this source was 1842 as some CNS regions were not available. In all cases, control status was confirmed by histology performed on sections prepared from paraffin embedded brain blocks and the diagnosis was determined by a consultant neuropathologist. Detailed phenotypic information is described in Table 1.
