The newly added data includes mouse and rat proteins from UniProt (5), with their associated phenotype data extracted from the International Mouse Phenotyping Consortium (6) and the Rat Genome Database (7), respectively. The Disease Ontology (DO) (8) data were further extended and newer ontologies such as Rat Disease Ontology (9) and Mammalian Phenotype Ontology (10) were added to facilitate comparison of target-disease and target-phenotype associations across multiple species. Similarly, additional data was included from GWAS (11) and OMIM (https://omim.org/) resources. The ‘Disease details’ page reflects these changes in addition to the other improvements made in displaying the list of associated targets. Throughout this manuscript, the term ‘target’ refers to ‘gene or protein of interest’, as sometimes attributes are related to genes (e.g. orthologs), and sometimes to proteins. However, TCRD is based on ‘reviewed’ (manually curated) human protein entries from UniProt.
