Target expression data was primarily extracted from GTEx (12), the Human Protein Atlas (HPA) (13), UniProt and TISSUES (14). The GTEx dataset was further extended to include sex-specific expression values. In addition, cell line expression data was added from HPA and the Human Proteome Map (15) and expression data was collected for orthologous genes from 17 different species. Other expression datasets integrated into the latest version are the Cancer Cell Line Encyclopedia (16) and cell perturbation expression data from the Library of Integrated Network-Based Cellular Signatures (17). Furthermore, the target expression panel was visually upgraded with interactive anatomograms (18) (https://www.ebi.ac.uk/gxa) for both sexes which further provides systematic mappings to the source tissues.
