to nBAF is instructive for the neuronal fate even in unrelated lineages, and may be a universal determinant of the core neuronal identity. Furthermore, BAF is essential for the plasticity of the adult brain and contributes to hippocampal LTP as well as adult neurogenesis; thus, BAF complexes are critical not only for the initial wiring of neural circuitry but also in maintaining and reshaping the connections based on the experience of the organism. The large number of BAF mutations in cognitive disorders prompts a deeper inquiry into the role BAF in brain development and function, particularly with regard to subunits with frequent or recurrent patterns of mutation, such as BAF250B and BAF47.
