2005). In addition, the dexamethasone (DEX) induced CYP2A6 increase in human primary hepatocytes was attenuated by the glucocorticoid receptor (GR) antagonist, and a mutation of hepatic nuclear factor 4 (HNF4) alpha response element (HNF4-RE), which suggested that GR and HNF4 alpha involved in the induction of CYP2A6 by DEX (Onica et al., 2008). However, how many genes contribute to the up-regulation of CYP2A5/2A6 induced by hepatocytes steatosis remains to be investigated.
