Combinations of THC and CBD have also been tested for different illnesses, and the results indicate that preparations with lower THC and higher CBD ratios are usually more efficient than the inverse (higher THC and lower CBD ratios) [11,145]. For example, Nabiximols, a cannabis-based preparation containing THC and CBD in a ratio of 1:1, was approved in Canada for the relief of Multiple Sclerosis (MS) spasticity or cancer pain [168,169]. Interestingly, in preclinical tests ineffectively low doses of THC or CBDA when given alone turn into very effective treatment for acute nausea and vomiting when given in combination [168]. These very low doses of combined CBDA and THC also showed anti-inflammatory effects and reduced pain sensation in these preclinical studies, although CBDA by itself was also capable of such effects [168].
