Neuroimaging studies have also confirmed that CBD administration decreased activity in limbic and paralimbic regions during emotional face processing tasks [175,178,204]. In Parkinson’s patients, CBD ameliorated the motor symptoms and also improved the quality of life of these patients [205]. CBD also decreases anxiety in socially anxious individuals [206,207]. In sum, based on the accumulated data so far, CBD seems to have great therapeutic potential without the significant adverse psychoactive effects associated with THC and this is likely due to its multiple mechanisms of action. Of note, the precursor of CBD, Cannabidiolic acid (CBDA) seems to be 100–1000 times more potent than CBD in reducing toxin-induced vomiting and nausea in animal models [208,209] and has also been shown to act as an anxiolytic agent by preventing stress-induced anxiogenic-like behavior [210].
