a collaborative effort to identify a core set of consistently annotated and high quality human and mouse protein-coding regions. The long-term goal is to support convergence towards a standard set of gene and protein annotations. To date, UniProt has investigated 700 records in close collaboration with the RefSeq annotation group at the NCBI and the HAVANA team at the WTSI. UniProtKB/Swiss-Prot release 57.6 contains 20 330 human proteome entries. More than one third of these contain additional sequences representing isoforms generated by alternative splicing, alternative promoter usage and/or alternative translation initiation, resulting in close to 34 000 human protein sequences. Approximately 58 000 single amino acid polymorphisms (SAPs), mostly disease-linked, are also described as well as 69 000 PTMs. This release of UniProtKB/Swiss-Prot also includes over 80 000 vertebrate proteins including 16 163 mouse proteins.
