The annotation effort towards proteins from model organisms recently led to the integration into UniProtKB/Swiss-Prot of the complete set of proteins encoded by S. pombe, the sixth eukaryotic organism to be completely sequenced (14). It is the third eukaryotic complete proteome (after S. cerevisiae and human) to be integrated in UniProtKB/Swiss-Prot. Since UniProt release 15.4, users can access 4958 sequence-verified, manually curated protein entries, including a link to GeneDB_Spombe, the fission yeast community database. The S. pombe proteome set will not be a static one but will be revisited and updated as science progresses in this field.