year (159 [34.0%] vs 278 [18.1%]), and prescription medication use across both CNS and non-CNS medications, paralleling a higher prevalence of these characteristics in absolute standardized differences seen in eTable 2 in the Supplement. We used an absolute standardized difference of less than 0.1 to denote negligible difference in covariate balance between groups20,33 (eTable 2A, 2B, 2C, 2D, and 2E in the Supplement).