This study is the first we are aware of to characterize white matter integrity in major fiber tracts throughout the cerebrum and cerebellum between subdiagnostic binge drinking teens and nondrinkers. The study is limited by its cross-sectional design and modest sample size, and serves as a preliminary characterization of white matter integrity in adolescent binge drinkers. Due to the exploratory nature of this study, the data require replication. If replicated, these results carry important public health implications as interventions targeting binge drinking behaviors could lessen the risk for developing an alcohol use disorder. Longitudinal investigations, currently underway, will also help ascertain the degree to which heavy drinking and postdrinking effects might influence the developing adolescent brain. Studies with larger sample sizes will examine gender differences, factors predating alcohol use (e.g., family history of alcoholism, personality, conduct disorder), and neuropsychological correlates of white matter abnormalities.
