Figure 2 shows the model-based receiver operating characteristic curves for a baseline model that included demographic and geographic information and a test model that also included the weighted GRS. The change in AUC from the baseline model to the test model was greater than zero (Delta AUC=0.048, 95% CI 0.313–0.658, p<10−7), indicating that the GRS improved discrimination of obese cases. This improvement in discrimination was concentrated at low specificities, but extended to the portion of the ROC curve of greatest interest to clinicians. At a specificity of 0.8, the test model including the GRS was marginally more sensitive as compared to the baseline model (Delta Partial AUC=0.007, 95% CI <0.0003–0.010, p=<0.001). Results for African Americans are presented in Supplementary Figure 2.
