comparison measures of obesity risk on all 3 metrics (p<0.01 for all comparisons). Among African Americans, the GRSs performed no differently from the simple genetic risk assessment (p>0.10) and performed less well as compared to the socioeconomic index (p=0.021). When combined with the comparison risk measures and with demographic and geographic information, the GRS improved predictiveness for whites but not for African Americans (Supplementary Table 9).