The rs610529 polymorphism in intron 8 was associated (p = 0.027 and p = 0.013 for the general and best model of association, which is based upon a recessive mode of inheritance for the G allele) with the AUDIT score. The genotypic AUDIT score means were 20.5, 19.1 and 14.7 for zero, one and two rs610529 G alleles, respectively (Table 2). Although there were no significant differences in allelic frequencies between control and problem drinkers (OR = 0.92, 95 per cent CI 0.58-1.44), treated alcoholics were approximately 1.5 times less likely to have the G allele (OR = 0.65, 95 per cent CI 0.43-0.98) and three times more likely to be either a homozygous AA or a heterozygous AG (OR = 0.32, 95 per cent CI 0.12-0.84) (Table 3). As with rs348479, these analyses provide some evidence for an association between rs6105249 and risk for alcohol dependence rather than problematic alcohol consumption behaviour.
