score of 11.0, 19.5 and 19.3 with zero, one and two rs348479 T alleles, respectively). The rs348479 genotypic frequencies were significantly different between the controls and treated alcoholics (p = 0.019); however, case-control odds ratio calculations did not indicate significant allele frequency differences between the controls and treated alcoholics (Table 3). Furthermore, the absence of significant allelic and genotypic differences between the controls and problem drinkers may indicate that rs348479 is involved in risk for alcohol dependence rather than increased or problem alcohol consumption. Nonetheless, the results of this study should also be interpreted in the context of multiple testing, since, correcting for the number of independent SNPs alone, a Bonferroni-corrected p-value of 0.0083 (0.05/6) would be required for an association to be declared significant.
