The rs348479 T allele was more frequent in subjects with higher AUDIT scores, where the mean AUDIT scores observed for the rs348479 G and T alleles were 17.8 and 19.7, respectively (Table 2) and the frequency of the T allele was 82 per cent in controls compared with 85 per cent (Table 3) in the treated alcoholic drinkers. In the analysis of the entire sample (n = 305), the association of the T allele with the AUDIT score approached nominal significance (p = 0.08 for general association) and the estimated genotypic AUDIT score means were suggestive of a dominant genetic model (p = 0.025) with respect to the T allele, where the AUDIT score is highest in those individuals with one or two copies of the T allele compared with individuals with two copies of the G allele (mean AUDIT score of 11.0, 19.5 and 19.3 with zero, one and two rs348479 T alleles, respectively). The rs348479 genotypic frequencies were significantly different between the controls and treated alcoholics (p = 0.019); however, case-control odds ratio calculations did not indicate significant
