The Münster cohort is described in Wray, et al. 9 and although this cohort was not part of their meta-analysis it was used for out of sample prediction using polygenic risk scores. In summary, the Münster cohort is a clinically ascertained sample with 960 MDD inpatient cases and 834 screened controls. The quality control procedures and the genome-wide association analysis of this cohort was conducting the same pipeline as used in Wray, et al. 9. The best thresholds for the meta-analysis PRS (P ≤ 0.01; 21,115 SNPs) and Wray PRS (P ≤ 0.05; 62,166 SNPs) were each used to test for an association with MDD in the Münster cohort.
