the PRS, GS was removed from the current meta-analysis and the Wray PRS prior to calculated single nucleotide polymorphism (SNP) weights which were filtered so that they only contained SNPs that overlapped between the current meta-analysis PRS and the Wray PRS. The first five principal components in GS were fitted to account for population stratification. The best thresholds for the meta-analysis PRS (P ≤ 0.05; 62,519 SNPs) and Wray PRS (P ≤ 0.001; 5,941 SNPs) were each used to test for an association with MDD in GS.
