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Chunk #36 — Regulation of BAF complex switching during neural development and reprogramming (caps)

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The role of BAF (mSWI/SNF) complexes in mammalian neural development.
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diverse neuronal fates has not yet emerged. Intriguingly, the two neurogenic miRNAs as well as the nBAF-specific subunits are found throughout the CNS and are exclusive to the neuronal lineage (Yoo et al., 2009; Wu et al., 2007). Given the instructive capacity, it is tempting to speculate that the miRNA-nBAF regulatory network defines a universal ground state of the neuronal chromatin, which then requires patterning by subtype-specific transcription factors for maturation.