pattern of PC1 in healthy controls using a set of large-scale datasets and demonstrated that the widespread abnormalities in several psychiatric disorders, epilepsy, alcohol dependence, and CHR were correlated with this global cortical pattern. The identification of a PC1 pattern was independent of the specific disorders examined. The reproducibility of the PC1 pattern across datasets makes it a promising benchmark to examine global changes in CT and relevant molecular profiles in health (e.g., Shin et al., 2020) and disease. The similarity between case-control profiles and PC1 partially supported the notion that mental illnesses may share global neuroanatomical abnormalities as opposed to discrete alterations to a small number of brain regions [51]. Moreover, this similarity suggests an alteration in the mechanisms that underlies the development of this widespread and neurotypical pattern of correlated CT. As discussed below, this pattern of CT is also closely associated with age-related changes indicating that thinner cortex common to mental illnesses may be related to alterations in childhood and adolescent neurodevelopment; a common origin in development may explain the ubiquity of this pattern in both healthy and patient populations.
