Chunk #16 — Results — Effects of Childhood Disorders on Subsequent Substance Use Disorders — Childhood MDD and Anxiety Disorders -- Effects on SUD Outcome
The presence of a childhood internalizing disorder (MDD or Anxiety Disorder) on the subsequent development of SUD was evaluated with an average interval of 3.19 ± 3.69 years. As may be seen in Table 4 (a–c), the presence of an antecedent diagnosis of MDD influenced the likelihood of developing Alcohol Abuse or Alcohol Dependence with marginal statistical significance. However, a childhood diagnosis of MDD significantly influenced the risk of developing Drug Abuse or Dependence and the likelihood of developing SUD. In contrast to childhood MDD, having an Anxiety Disorder in childhood did not significantly predict Alcohol Abuse or Dependence, Drug Abuse or Dependence, or either (SUD diagnosis). However, a childhood history of either Anxiety Disorder or MDD was significantly associated with later development of Drug Abuse and Dependence (Wald = 4.39, df =1, p =0.036), and with development of SUD (Wald = 5.73, df =1, p =0.017).
