Models were run to test the contribution of specific childhood disorders to Substance Use Disorder outcome that also included the familial risk variable as a covariate in the model. These analyses made it possible to adjust for the potential influence of familial risk group membership on the relationship between having a specific prior childhood disorder and SUD outcome. The odds of developing SUD in association with the presence of specific childhood externalizing disorders is shown in Table 5 relative to the odds associated with high or low familial risk status without consideration of whether or not the offspring had a childhood disorder. These results demonstrate that externalizing problems of childhood and adolescence are associated with a dramatic increase in risk for SUD by young adulthood in these offspring of AD mothers. Moreover, the effects of these externalizing disorders as predictors of later SUD are substantial because they remain significant even when familial risk is entered into the Cox Regression models.
