When analyses were run controlling for familial risk group membership, the presence of MDD in childhood/adolescence did not significantly affect survival time for Alcohol Abuse and Alcohol Dependence, Drug Abuse and Drug Dependence or all four conditions (SUD), though a trend was seen for SUD ((Wald = 2.81, df =1, p =0.09). Similarly, presence of an anxiety disorder in childhood/adolescence did not significantly influence survival time for Alcohol Abuse and Alcohol Dependence, Drug Abuse and Drug Dependence or all four conditions (SUD). Using a broader phenotype of prior Major Depressive Disorder or an Anxiety Disorder in childhood or adolescence, we also did not find an association between internalizing disorders of childhood and reduced survival time for SUD by young adulthood when familial risk status was entered into the model.
