Chunk #40 — Results — Empirical results for SNP-based heritability and CGR

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Meta-GWAS Accuracy and Power (MetaGAP) Calculator Shows that Hiding Heritability Is Partially Due to Imperfect Genetic Correlations across Studies.

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The univariate estimates of SNP heritability based on the pooled data assume perfect CGRs. Therefore, such estimates of SNP heritability are downwards biased when based on data from multiple studies with imperfect CGRs. To circumvent this bias, we estimated SNP heritability in each study separately, and focused on the sample-size-weighted cross-study average estimate of SNP heritability.