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Chunk #41 — Results — Empirical results for SNP-based heritability and CGR

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Meta-GWAS Accuracy and Power (MetaGAP) Calculator Shows that Hiding Heritability Is Partially Due to Imperfect Genetic Correlations across Studies.
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For both height and BMI, we observed genetic correlations close to one across pairs of studies and between females and males. For years of schooling (EduYears) we found a CGR around 0.8 when averaged across pairs of studies. Similarly, the genetic correlation for EduYears in females and males lies around 0.8. The CGR of self-rated health is substantially below one across the pairs of studies, whilst the genetic correlation between females and males seems to lie around one. The reason for this difference in the genetic correlation of self-rated health between pairs of studies and between females and males may be due to the difference in the questionnaire across studies, discussed in S1 Data. The questionnaire differences can yield a low CGR, while not precluding the remaining genetic overlap for this measure across the three studies, to be highly similar for females and males. For CurrCigt and CurrDrinkFreq, the estimates of CGR and of genetic correlation between females and males are non-informative. For these two traits the standard errors of the genetic correlations estimates are large, mostly greater than 0.5. In addition, for CurrDrinkFreq there is strong volatility in the CGR estimate across pairs of studies.