Considering only the traits for which we obtained accurate estimates of CGR and SNP heritability (i.e., with low standard errors), we used the MetaGAP calculator to predict the number of hits in a set of discovery samples and the PGS R2 in a hold-out sample, in prominent GWAS efforts for these traits. Details and notes on the results from existing studies, used as input for the MetaGAP calculations, can be found S3 Table. Importantly, as reported in S4 Table, for the traits under consideration here, large-scale GWAS results to date have been obtained using fixed-effects meta-analyses.
